Proteomic And Transcriptomic Profiling: Spatial Biology’s Role Within A Histology Lab

Spatial biology is an ever-evolving field that has been innovating scientific research, emphasizing the intricate relationships within biological tissues. In this review, we will dive into the world of spatial biology and explore some of the current proteomic and transcriptomic spatial profiling methods. With the advent of new spatial technologies, researchers are equipped with the tools to discover novel RNA and protein interactions in tissues. Many spatial biology methodologies employ a combination approach by utilizing a molecular quantification method along with histochemical stains, single, or multiplex immunofluorescent assays to provide holistic context on cell-to-cell interactions and microenvironments within tissue. Furthermore, the discussion extends to translational and clinical applications, elucidating how these techniques contribute to advancements in healthcare. To achieve accurate results, many spatial biology technologies rely on adequate tissue preservation for optimal morphology and for RNA and protein molecules to remain intact. Thus, the role of the histology specialist in this emerging field is critical. To highlight this, we will be reviewing the function of the histology specialist in spatial biology and how these approaches can be integrated into a histology lab using state of the art equipment as well as manual applications. Overall, this session underscores the research advancements that arise from prioritizing histology in the field of spatial biology.

CEUs: This histology course is worth 1 continuing education credit and is available for 365 days from the date of registration.
This session is from the 2024 NSH Virtual Convention Program