Cryo-Fluorescence Tomography: A Technique to Bridge Multi-Resolution Multi-Modal Assays
Recorded On: 05/26/2021
The ability to engineer mouse models with human cancer is valuable tool used by research groups around the world to better understand the biology of disease and drug targeting characteristics. Many human cancer cell lines have been engineered to express fluorescence so that in vivo imaging can be used to monitor and stage disease progression. Following in vivo imaging, traditional histo-pathology can be performed to validate in vivo measurements. However, a gap in sensitivity and resolution between in vivo and ex vivo techniques may make it hard to characterize an animal model. In vivo fluorescence allows for monitoring of tumor progression over time. Traditional ex vivo techniques only focus on small sample sizes while allowing for high-resolution evaluation and characterization. Using a Cryo-Fluorescence Tomography (CFT) imaging approach, an imaging modality based on serial slicing and off-the-block fluorescence imaging, we can bridge the gap between in vivo and ex vivo resolution of the entire animal.
CEUs: This histology course is worth 1 continuing education credit. Course is available for 365 days from date of purchase.
Mohammed Farhoud, MS
Mohammed is a scientist trained in medical imaging, who takes an application driven approach to the development, commercialization and support of medical imaging devices. An entrepreneur driven by the scientific community to create innovative devises that enhance and complement the best practices in medical imaging. Previously Mohammed held positions at Sofie in Product Development and at Siemens in Application support.